Xylitol Research

Xylitol Research

Xylitol Home Page Xylitol Research JDRThe Research is Conclusive

There have been numerous studies done throughout the world that have conclusively shown that the use of Xylitol has a positive benefit to oral health. PleaseĀ view some of the Xylitol research that has been published below.

To view some of the Xylitol Articles written by Dr Chris Edwards please click here

To learn more about Xylitol please select from the links at the bottom of this page.

Navigate to xylitol research which can be found on the current website.

Natural Xylitol Health Benefits

Xylitol is a naturally-occurring carbohydrate (polyol) that has a 5 carbon structure – distinguishing if from other common sugars based on 6 carbons.

Mutans Streptococci Dose Response to Xylitol Chewing Gum

The study determined the dose-response of mutans streptococci in plaque and unstimulated saliva to xylitol gum.

Milk with Xylitol for Dental Caries Prevention
Xylitol has been shown to reduce dental caries when mixed with food or chewing gum.

Complementary and Alternative Medicine in Allergy, Otitis Media (Ear Infection), and Asthma
Studies suggest that probiotic preparations have a role in the treatment of allergic conditions, and Xylitol gum, syrup, and lozenges have shown efficacy in treatment of acute otitis media.

The Polyols in Pediatric Dentistry: Advantages of Xylitol
Xylitol is not only a means of stabilizing diabetes and obesity, but also a weapon in the prevention of dental caries.

Yogurt Containing Xylitol Lowered Appetite
The use of xylitol in functional foods resulted in suppression of appetite.

Evaluation of Fluoride Varnish and Xylitol Gum Prevention Programs
This study evaluated the effectiveness of two prevention programs, including applications of fluoride varnish and the use of xylitol chewing gum in randomized groups of preschool children in the United States

Six-month Polyol Chewing-gum Program in Kindergarten-age Children: a Feasibility Study Focusing on Mutans Streptococci and Dental Plaque
Xylitol-containing chewing gum may significantly reduce the growth of mutans streptococci and dental plaque which may be associated with dental caries.

The Effect of Xylitol and Ethanol on Bone Resorption
A simultaneous dietary supplementation with 10% xylitol and 10% ethanol seems to diminish bone resorption and to increase trabecular bone mineral density and trabecular bone mineral content in rats.

The Effect of an Oral Rinse Containing Xylitol for Elderly People with Xerostomia (Dry Mouth)
The results showed the usage of an oral rinse with Xylitol improved hyposalivation and unpleasant oral complaints of the elderly.

The Effect of Xylitol Chewing Gum on Mutans Streptococci in Saliva and Dental Plaque
This study conducted with 91 children suggests that the use of xylitol chewing gum can reduce the levels of mutans streptococci in plaque and saliva.

Further Evidence of How Xylitol Prevents Ear Infections: Ultrastructure of Streptococcus Pneumoniae after Exposure to Xylitol
Xylitol is a sugar alcohol which reduces the growth of Streptococcus pneumoniae and the adherence of pneumococci and Haemophilus influenzae to nasopharyngeal cells.

Army’s “Look for Xylitol First” Program
Xylitol is a sugar substitute not well known in the United States. This sugar substitute is not only low in calories but can also help prevent dental caries.

Use of Chewing Gums Containing Xylitol, Chlorhexidine or Fluoride on Mutans Streptococci Colonization by the Mothers’ Infant Children
Maternal consumption of xylitol- and chlorhexidine/xylitol-containing chewing gums significantly reduced the mother-child transmission of salivary mutans streptococci.

Effect of Xylitol-containing Chewing Gums on Lactic Acid Production in Dental Plaque from Caries Active Pre-school Children
A 14-day use of xylitol-containing chewing gums, corresponding to a daily amount of 5 grams of xylitol, could diminish glucose-initiated lactic acid formation in plaque in caries-active pre-school children

Remineralization Effects of Xylitol on Demineralized Enamel
This study shows that xylitol can induce remineralization of deeper layers of demineralized enamel by facilitating Ca2+ movement and accessibility


Studies of the Nasal Benefits

The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.
Xylitol sprayed for 4 days into each nostril of normal volunteers significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline control.

Xylitol in preventing acute otitis media.
Xylitol inhibits the growth of Streptococcus pneumoniae and it inhibits the attachment of both pneumococci and Haemophilus influenzae on the nasopharyngeal cells. In two clinical trials xylitol was found efficient to prevent the development of acute otitis media with a daily dose of 8.4-10 g of xylitol given in five divided doses.

A novel use of xylitol sugar in preventing acute otitis media.
Thus, the occurrence of AOM (ear infection) during the follow-up period was significantly lower in those who received xylitol syrup or gum, and these children required antimicrobials less often than did controls. Xylitol was well tolerated.


Studies on the Cavity-Fighting Ability

Xylitol and dental caries: an overview for clinicians
Prospective trial in Finland has demonstrated that children of mothers treated with xylitol had lower levels of S. mutans (bacteria) than children of mothers treated with chlorhexidine or fluoride varnish.

Xylitol for caries prevention
The appealing sensory and functional properties of xylitol facilitate a wide array of applications that promote oral health.

The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries prevention.
Habitual xylitol gum-chewing may have a long-term preventive effect by reducing the caries risk for several years after the habitual chewing has ended.

The effect of non-cariogenic sweeteners on the prevention of dental caries: a review of the evidence.
These studies observed the reduction of cavity rates among subjects using xylitol and sorbitol as the sugar substitutes in chewing gum and toothpaste. The highest cavity reductions were observed in subjects using xylitol.

Remineralizing potential, antiplaque and antigingivitis effects of xylitol and sorbitol sweetened chewing gum
These studies observed the reduction of cavity rates among subjects using xylitol and sorbitol as the sugar substitutes in chewing gum and toothpaste. The highest cavity reductions were observed in subjects using xylitol

Smart Habit Xylitol campaign, a new approach in oral health promotion.
The aim of the campaign was to increase consumption of xylitol chewing gum in 13-year-old school children, to promote their oral health.

Effect of xylitol chewing gum on salivary Streptococcus mutans in preschool children
The shift from higher S. mutans (bacteria) scores to lower was greater in the xylitol group than in the control group. This study supports the suggestion that chewing xylitol gum may reduce S. mutan levels.

Caries preventive effect of sugar-substituted chewing gum.
Xylitol chewing gum regimen by preschool children and teachers
Acceptance of the xylitol chewing gum regimen by preschool children and teachers in a Head Start program: a pilot study.

Chewing gum in combination with toothbrushing
An evaluation of a commercial chewing gum in combination with normal toothbrushing for reducing dental plaque and gingivitis.

Sugar substitutes, chewing gum and dental caries–a review.
Clinical trials indicate that xylitol gum has a useful anticaries role, superior to the effects of sorbitol gum. In addition, xylitol’s antibacterial properties seem likely to lead to caries reductions superior to the more modest reductions with sorbitol gum.

Effects of frequent mouth-rinses with palatinose and xylitol on dental plaque.
Regarding the plaque index, xylitol gave lower scores compared to the other 3 periods.

Timing of first restorations before, during, and after a preventive xylitol trial.
This analysis indicated that participation of subjects in the xylitol chewing gum trials resulted in a significant reduction in the number of first restorations and hence in costs during the decade after the onset of gum use.

Xylitol fermentation by human dental plaque.
Properties of whole saliva and dental plaque in relation to 40-month consumption of chewing gums containing xylitol, sorbitol of sucrose.

Chewing of xylitol gum-a well adopted practice among finnish adolescents
This analysis indicated that participation of subjects in the xylitol chewing gum trials resulted in a significant reduction in the number of first restorations and hence in costs during the decade after the onset of gum use.


Xylitol as a Sweetener

A dietary procedure for preventing dental caries in young adults.
Scientific evidence also suggests that the addition of small daily quantities of xylitol to the diet of children and young adults causes significant reduction in the incidence of dental caries.

Children’s acceptance of xylitol-based foods.
These results suggest that snack foods developed with xylitol are generally well accepted by children.

Organoleptic properties of a new sweetening agent formulation based on aspartame and xylitol.
The results show that the aspartame-xylitol mixture with sweetness intensity equal to 5.0 is a good synthetic sweetener to substitute sucrose.

Sugar, alternative sweeteners and meal frequency in relation to caries prevention: new perspectives.
The use of chewing gum and other xylitol-containing products have resulted in defined reduction in caries and represent interesting alternatives for high-caries-risk populations.


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